Dealing with Degrees: The Neuromechanics of Motor Control in Soft Animals

Are you interested in how animals move and how their nervous systems control behavior? This project uses the caterpillar Manduca sexta—a soft-bodied insect with a simple yet effective nervous system—to study movement control in unprecedented detail. By implanting flexible electrode arrays into its muscles, researchers can record motor neuron activity during natural behaviors and link these recordings to high-speed motion analysis. To take this further, the project will build detailed 3D simulations based on micro-CT scans to explore how neural signals and body mechanics work together to produce movement. The first focus is on proleg grip-release, a survival-critical motion controlled by just one neuron, before expanding to full-body locomotion. This research provides hands-on experience with neurophysiology, biomechanics, and computational modeling—perfect for students interested in movement science, robotics, or evolutionary biology!

Name of research group, project, or lab
Trimmer Lab (Neuromechanics and Biomimetic Devices Laboratory)
Why join this research group or lab?

This research is based in a fun lab that emphasizes curiosity and independence. We have a very wide range of facilities that includes a full neurophysiology suite, cell culture and molecular tools and a "project room" for building whatever you need for your experiments. Although the live animal work is focused on the insect Manduca sexta, we also encourage students to think about the wider implications of their research. With this in mind ,we build soft robots that can squeeze through difficult terrain and grow insect cells in culture for possible use as living actuators or food production. 

Representative publication
Logistics Information:
Project categories
Physiology, Neurobiology, and Biomechanics
Student ranks applicable
2nd year undergraduate
3rd year undergraduate
4th year undergraduate
Masters
Student qualifications

To be successful in the laboratory students will need to be highly motivated and dedicate sufficient time to do their experiments. Once trained, you will be given considerable independence, but we expect you to take ownership of the work, keep detailed records, and to be responsible for getting results. Students will be treated as full members of the lab team and will share maintenance responsibilities and must attend the weekly lab meetings. Most of our work requires fine motor skills but we will train you in the use of the appropriate tools including microscopes and micromanipulators. For the research on Manduca you will need to be comfortable with handling caterpillars and moths and willing to perform experiments on living animals and tissues.

Our work in robotics is suitable for someone with experience building things and who is comfortable with electrical circuits and simple Arduino or Raspberry Pi programming. Although we do not require an engineering background basic skills in CAD software will be an asset.

Hours per week
10-15hrs/wk
Compensation
Unpaid - Course Credit
Number of openings
1
Techniques learned

Insect rearing and maintenance

Neurophysiology techniques including electromyographic (EMG) recordings and extracellular recordings from living nerves

Imaging and video tracking

Behavioral analysis

Microdissection and handling living tissue

Project start
January 2025
Contact Information:
Mentor
barry.trimmer@tufts.edu
Principal Investigator
Name of project director or principal investigator
Barry Trimmer
Email address of project director or principal investigator
barry.trimmer@tufts.edu
1 sp. | 0 appl.
Hours per week
10-15hrs/wk
Project categories
Physiology, Neurobiology, and Biomechanics